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Notables in Path of Exile 2 play a crucial role in defining the power and identity of your build. These passive nodes deliver high-impact bonuses-ranging from massive damage increases to key defensive layers-and are often the backbone of optimized endgame setups.

Thanks to the revamped Delirium League mechanics in PoE 2, players can use Liquid Emotions, a collectible Path of Exile 2 Item, to apply a Notable directly onto an Amulet. This makes Anointing one of the most efficient ways to fine-tune your build and grab game-changing bonuses from across the passive tree.

Below, we break down the 10 best Nodes to Anoint in Path of Exile 2, chosen for their universal value, synergy across many class archetypes, and high impact on both leveling and endgame builds.

How Anointing Works in Path of Exile 2

Anointing in PoE 2 uses Liquid Emotions, collectible items dropped from Delirium encounters, and maps influenced by the Delirium mechanic.

To apply an Anoint:

1. Acquire a Liquid Emotion (each corresponds to a specific Notable).

2. Right-click the Liquid Emotion to open the Anointing window.

3. Select the Notable you want to apply.

4. Apply it to any Amulet to instantly gain that passive's effect.

Some important notes:

·Not all Notables can be Anointed.

·You can identify Anoint-eligible Notables by searching for "CanInstill" in the passive tree.

·Anoints can be changed at any time if you have the required Liquid Emotions.

While these items can be purchased through the Currency Exchange, rare emotions can be expensive-so swapping Anoints repeatedly may not be sustainable early on.

10 Best Notables to Anoint in Path of Exile 2

With over 750 Notables in PoE 2, making the right choice can be overwhelming. These 10 are among the strongest and most universally beneficial options, offering excellent value regardless of your class or playstyle.

1. Heart of the Warrior

Why it's good:

One of the best early- to mid-game defenses, granting massive life and strength scaling. Great for melee, ranged, and hybrids alike.

Best for: Marauder, Ranger, Duelist, any build needing tankiness.

2. Arcane Dominion

Why it's good:

Provides a huge boost to Mana, Mana regeneration, and spell scaling-a powerful pickup for spellcasters, support casters, and minion hybrid builds.

Best for: Witches, Templars, Shadow casters.

3. Fangs of the Viper

Why it's good:

A staple for Dexterity-based builds, offering Movement Speed and Attack Speed. Incredible on bow, trap, or agility-focused melee builds.

Best for: Ranger, Shadow, thrown weapon builds.

4. Prismatic Skin

Why it's good:

One of the best defensive Notables in PoE 2, Prismatic Skin grants a strong bonus to all elemental resistances with max resistance scaling-perfect for endgame bossing.

Best for: Any build, particularly HC players.

5. Divine Judgement

Why it's good:

A top-tier Elemental Damage node with generic scaling, letting it benefit spellcasters, weapon elemental builds, and hybrid elemental attackers.

Best for: Templar, Witch, Elemental Bow users.

6. Blood Drinker

Why it's good:

Grants powerful Leech benefits that massively improve sustain for melee and ranged attack builds. Crucial for mapping efficiency and survivability.

Best for: Duelist, Marauder, physical or elemental attackers.

7. Gravepact

Why it's good:

A premier minion damage Notable offering huge increases to minion damage, accuracy, and reliability. Works for summoners, hybrid minion/spell builds, and necrotic archetypes.

Best for: Witch Necromancer, Templar Herald builds.

8. Disciple of the Slaughter

Why it's good:

One of the strongest Frenzy Charge-based nodes, adding Attack Speed, Damage, and powerful Frenzy bonuses. Perfect for crit, bow, and fast-paced melee builds.

Best for: Ranger, dual-wield Shadow, rapid attack setups.

9. Righteous Decree

Why it's good:

Reduces Mana Costs significantly-amazing for channeled skills, resource-hungry spells, and hybrid builds struggling with sustain.

Best for: Templar, Witch, long-duration channel builds.

10. Constitution

Why it's good:

A colossal Life Notable offering one of the largest HP bonuses in the game. It's a must-have for tank builds, HC players, and anyone wanting reliable defense.

Best for: Marauder, Duelist, any class in endgame bossing.

Which Nodes Should You Anoint?

When choosing which Notable to Anoint in Path of Exile 2, consider:

·Is it too far from my path to reach normally?

·Does it provide an effect I can't find elsewhere?

·Does this Notable fix a build weakness? (Mana, Life, Resistances, etc.)

·Is the Liquid Emotion cost worth the benefit?

·Offence-focused builds typically benefit most from Fangs of the Viper, Divine Judgement, and Disciple of the Slaughter.

·Defence-heavy or HC players gravitate toward Constitution and Prismatic Skin.

·Casters often choose Arcane Dominion or Righteous Decree.

Summoners always consider Gravepact.

If you're short on Liquid Emotions or Path of Exile 2 Currency, you can also buy POE2 Currency to complete your optimal Anoint setup without grinding endlessly.

Final Thoughts

Anointing is one of the most powerful build-customisation tools in Path of Exile 2, allowing players to bypass the limitations of the sprawling passive tree and pick up high-impact Notables from anywhere. Whether you need more damage, extra survivability, or build-defining utility, the right Anoint can completely transform your character.